Gene and Metabolic Environment Interactions in Obesity and Diabetes
نویسندگان
چکیده
Since 2007, genome-wide association studies (GWAS) have contributed to a major leap forward in understanding the genetic basis of obesity and diabetes [1–4]. To date, 37 genetic loci associated with obesity or body mass index (BMI) have been identified through these GWAS which were predominantly in populations of European ancestry. We conducted a meta-analysis of associations between BMI and approximately 2.4 million single-nucleotide polymorphism (SNPs) in 27,75 East Asians, including seven loci previously identified by studies conducted among European-ancestry populations (FTO, SEC6B, MC4R, GIPR/QPCTL, ADCY3/RBJ BDNF, and MAP2K5) and three novel loci in or near the CDKAL,PCSK, and GP2 genes [5].
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